The main difference is how they work. Cigarettes burn tobacco and produce smoke, while vapes heat e-liquid and produce vapor.
Cigarettes: Burn tobacco, create smoke, and leave strong smell.
Vape: Heat liquid, create vapor, and usually have less lingering smell.
Cigarettes: Fixed nicotine level.
Vape: Different nicotine strengths (MG) available.
Cigarettes: One flavor (tobacco).
Vape: Many flavors available.
Cigarettes: Ash and smoke.
Vape: No ash, only vapor.